Saturday, March 2, 2013

Gary Oldman Joins Dawn of the Planet of the Apes

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Matt Reeves? Dawn of the Planet of the Apes has added another lead in Gary Oldman (The Dark Knight Rises). ?The Mark Bomback script takes place 15 years after the events of Rise of the Planet of the Apes and finds humanity all but wiped out by the race of super-intelligent apes. ?Part of the story centers on a group of scientists in San Francisco who are mounting a resistance against their new oppressors while Caesar (Andy Serkis) struggles to maintain dominance over his kingdom. ?It?s looking like Oldman will play Dreyfus, the leader of a human colony in the sequel, due out May 23, 2014. ?Hit the jump for more.

gary-oldman-dawn-of-the-planet-of-the-apesReports of Oldman joining Dawn of the Planet of the Apes comes via CS. ?Recently, Jason Clarke (Zero Dark Thirty) and Kodi Smit-McPhee (Let Me In) joined the cast as two of the film?s leads, though their roles were not specified. ?The sequel is expected to start filming this spring.

Oldman recently starred in John Hillcoat?s Lawless and Christopher Nolan?s The Dark Knight Rises. ?He?ll next be seen alongside Harrison Ford in Robert Luketic?s thriller Paranoia?in which his character blackmails an ambitious young techie (Liam Hemsworth) into spying on a rival company. ?That film will be followed by Jos? Padilha?s reboot of RoboCop?in which he?ll play Dr. Robert Norton. ?Both pictures are currently filming. ?Oldman will also star in Monster Butler, the Douglas Rath thriller based on the serial-killing con-man, Ray Fontaine, as played by?Malcolm McDowell.

Be sure to get caught up on all of our continuing coverage for Dawn of the Planet of the Apes here.

Source: http://www.rottentomatoes.com/m/1926940/news/1926940/

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Friday, March 1, 2013

Finance bill still a moving target | EdNewsColorado

It looks like Sen. Mike Johnston?s proposed overhaul of Colorado?s school finance system will be formally introduced in the legislature next week, and it?s also likely the bill will be at least a bit different from the draft version that?s been circulating publicly for nearly two weeks.

Sen. Mike Johnston, D-Denver

Sen. Mike Johnston explains his school finance plan during a Feb. 28 meeting.

The Denver Democrat talked about the bill and his plans during a two-hour ?public forum? Thursday at the History Colorado center, attended by about 150 people. The event was the last of some 150 meetings Johnston has held over the last two years to promote and build support for his plan.

Johnston?s proposal is intended to make the state?s school funding system more equitable by directing money to schools with the greatest needs and more adequate by increasing the amount of funding. Key elements of the plan include more funding for at-risk students, English language learners and special education students; full funding of preschool for at-risk students and full-day kindergarten; a shift in the state and local shares of school funding, and increased overall funding to partially compensate for recent cuts in K-12 support.

The proposal requires two steps ? legislature passage of the new formula and voter approval next November of perhaps $1 billion in tax increases to pay for the plan. If voters say no the formula wouldn?t go into effect. (Get more details on the current draft of the proposal in this EdNews story.)

Thursday?s meeting highlighted some of Johnston?s plans for the bill and some of the questions and objections to the plan. The session included breakout groups in which Johnston and aides explained and answered questions about various parts of the proposal.

?That draft is already outdated,? Johnston said referring to this version. But neither he nor his aides gave details on specific changes that will be included in the version to be introduced in the Senate. (Another set of data yet to be released are district-by-district financial estimates of the plan?s impact.)

There were lots of questions about and some criticisms of the plan. The strongest was voiced by Randy DeHoff, a former State Board of Education member who now works for an online school. The plan is ?a lot more money going into a 19th century system,? he said, ?leaving the districts in charge and leaving out the students.?

Here are some of the concerns that emerged during Thursday?s discussion:

Charter schools: Several speakers complained that the plan does nothing to solve the funding inequities imposed on charter schools by current state law. ?There?s nothing in the bill right now, but that doesn?t mean there won?t be,? said Johnston aide Will Gohl.

Participants at Feb. 28 school finance meeting.

Meeting participants listen to Sen. Mike Johnston.

The negative factor: Current state law includes a mathematical formula called the negative factor that allows the legislature to reduce annual school funding to an amount the helps balance the state budget, regardless of what school funding should have been. His bill doesn?t address that issue, and Johnston said it?s ?politically impossible? to eliminate the negative factors, which has slashed an estimated $1 billion from school funding in the last four years.

The Lobato decision: One speaker complained that Johnston?s plan doesn?t meet the requirements of a district court decision in Lobato v. State, which found the state?s school finance system unconstitutional. The case is pending before the Colorado Supreme Court. Johnston said, ?We don?t believe this [bill] solves the Lobato lawsuit, nor is it meant to. It is one step along the way.?

Nobody at the meeting raised this question, but some conservatives, primarily state Treasurer Walker Stapleton, have complained that the proposed bill doesn?t address the cost of teacher pensions under the Public Employees? Retirement Association. Johnston basically dismissed that criticism, saying PERA?s future solvency has been handled by legislation passed in 2009. ?That?s why we haven?t seen it as part of the school finance plan.?

Responding to concerns, Johnston and his legislative partner, Boulder Democratic Sen. Rollie Heath, had some tough love for critics.

?Doing nothing is not an option,? Johnston said. ?Insisting on a proposal you know can?t pass is a version of doing nothing.?

Heath was even more plain-spoken.

?This is put-up or shut-up time. ? We can?t solve every problem everybody wants to solve. ? Please understand you?re not going to get everything you want.?

Source: http://www.ednewscolorado.org/news/finance-bill-still-a-moving-target

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Protein balance key in preventing cancer

Feb. 27, 2013 ? Two proteins that scientists once thought carried out the same functions are actually antagonists of each other, and keeping them in balance is key to preventing diseases such as cancer, according to new findings published in the February 25 issue of Developmental Cell by scientists at Fox Chase Cancer Center. The results suggest that new compounds could fight cancer by targeting the pathways responsible for maintaining the proper balance between the proteins.

"It's our job now to understand how we can intervene therapeutically in this system, so we can restore balance when it's thrown off," says study author David L. Wiest, PhD, professor and deputy chief scientific officer at Fox Chase.

The two proteins -- "Rpl22" and "Rpl22-like1," which contribute to the process by which additional cellular proteins are made -- are created from two similar genes, leading researchers to previously believe they were performing identical functions in the body. "What we're finding is that is absolutely not true," says Wiest. "Not only are they performing different functions, they are antagonizing each other."

During the study, Wiest and his team knocked out Rpl22 in zebrafish -- a common model of human disease. Without Rpl22, the zebrafish don't develop a type of T cells (a blood cell) that helps fight infections. The same developmental defect was observed when they knocked out Rpl22-like1, indicating that both proteins are independently required to enable stem cells to give rise to T cells.

But when the researchers tried to restore T cells in zebrafish that lacked Rpl22 by adding back Rpl22-like1, it didn't work. The reverse was also true -- Rpl22 was not enough to restore function after the researchers eliminated Rpl22-like1. These results led Wiest and his team to believe that, although the proteins are both involved in producing stem cells, they do not perform the same function.

To learn more about the proteins' individual functions, the researchers looked at the levels of different proteins involved in stem cell production when either Rpl22 or Rpl22-like1 was absent. Without Rpl22-like1, cells had lower levels of a protein known as Smad1 -- a critical driver of stem cell development. And when Rpl22 disappeared, levels of Smad1 increased dramatically.

Both proteins can bind directly to the cellular RNA from which Smad1 is produced, suggesting that they maintain balance in stem cell production via their antagonistic effects on Smad1 expression, explains Wiest.

"I like to think of Rpl22 as a brake, and Rpl22-like1 as a gas pedal -- in order to drive stem cell production, both have to be employed properly. If one or the other is too high, this upsets the balance of forces that regulate stem cell production, with potentially deadly effects," says Wiest.

Specifically, too much Rpl22 (the "brake"), and stem cell production shuts off, decreasing the number of blood cells and leading to problems such as anemia. Too much Rpl22-like1 (the "gas pedal"), on the other hand, can create an over-production of stem cells, leading to leukemia.

Previous research has found that Rpl22-like1 is often elevated in cancer, including 80% of cases of acute myeloid leukemia (AML). Conversely, researchers have found that in other cancers, the gene that encodes Rpl22 is deleted. "Either one of these events is sufficient to alter the balance in stem cell production in a way that pushes towards cancer," says Wiest.

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Story Source:

The above story is reprinted from materials provided by Fox Chase Cancer Center, via EurekAlert!, a service of AAAS.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Yong Zhang, Anne-C?cile?E. Duc, Shuyun Rao, Xiao-Li Sun, Alison?N. Bilbee, Michele Rhodes, Qin Li, Dietmar?J. Kappes, Jennifer Rhodes, David?L. Wiest. Control of Hematopoietic Stem Cell Emergence by Antagonistic Functions of Ribosomal Protein Paralogs. Developmental Cell, 2013; 24 (4): 411 DOI: 10.1016/j.devcel.2013.01.018

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/5ulhTnVP2Io/130227162020.htm

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Understanding Infidelity 03/01 by Mental Health Chat with Marci ...

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    On his show, Comedian Rodney Perry covers arts and entertainment, everything from comedy and politics to music and acting, with his signature comedic slant.

  • MashUp Radio is a 30-minute podcast that discusses the fusion of technology, life, culture and science. Host Peter Biddle, engineer and executive for Intel?s Atom Software, dishes up a thought-provoking discussion.

  • Joy Keys provides her listeners with insight to improve their lives mentally, physically, monetarily and emotionally. Past guests on the show have included Meshell Nedegeocello, Blair Underwood, in addition to an impressive list of CEOs, humanitarians and authors.

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  • Listeners get an earful on The Halli Casser-Jayne Show, Talk Radio for Fine Minds. Whether it?s the current political cocktail or the latest must-read award-winning book, Halli tackles all topics and likes to stir ? and sometimes shakes ? things up.

  • Official Internet radio show of forthcoming epic paranormal investigation book by Eric Olsen and "Haunted Housewife" Theresa Argie.

  • Award-winning World Footprints is a leading voice in socially responsible travel and lifestyle. Hosts Ian & Tonya celebrate culture and heritage and bring a unique voice to the world of travel.

  • Football Reporters Online is a group of veteran football experts in the fields of coaching, scouting, talent evaluation, and writing/broadcasting/media placement. Combined, the group brings well over 100 years of expertise in sports.

  • Host John Martin interviews the nation's leading entrepreneurs and small biz experts to educate small business owners on how to be successful. Past guests have included Emeril Lagasse and Guy Kawasaki.

  • The Movie Geeks share their passion for the art through interviews with the stars of and creative minds behind your favorite flicks and pay tribute to big-screen legends. From James Cameron and Francis Ford Coppola to Ellen Burstyn and Robert Duvall, The Geeks have got'em all.

  • Sylvia Global presents global conversations pertaining to women, wealth, business, faith and philanthropy. Sylvia has interviewed an eclectic mix from CEOs and musicians to fashion designers and philanthropists including Randolph Duke and Ne-Yo.

  • Mr. Media host Bob Andelman goes one-on-one with the hottest, most influential minds from the worlds of film, TV, music, comedy, journalism and literature. That means A-listers like Kirk Douglas, Christian Slater, Kathy Ireland, Rick Fox, Chris Hansen and Jackie Collins.

  • Paula Begoun, best-selling author of Don't Go to the Cosmetics Counter Without Me, separates fact from fiction on achieving a radiant, youthful complexion at any age. She?s regularly joined by health and beauty experts who offer the latest on keeping your skin in tip-top shape.

  • Source: http://www.blogtalkradio.com/therapistmarci/2013/03/02/understanding-infidelity

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    Three overstretched DNA structures confirmed

    Feb. 28, 2013 ? A novel discovery brings a close to a 17-year-old scientific debate about the impact of mechanical stretching on the structure of DNA.

    A team of researchers led by Associate Professor Yan Jie from the Department of Physics at the National University of Singapore (NUS) Faculty of Science has identified three new distinct overstretched deoxyribonucleic acid (DNA) structures caused by mechanical stretching. This discovery provides a clear answer to a long-running debate among scientists over the nature of DNA overstretching.

    Debate on Possible DNA Structural Transitions

    Recent single-molecule studies revealed that mechanical stretching could induce transitions to elongated DNA structures. Three possible elongated DNA structures have been proposed, namely: a single-stranded DNA under tension, DNA bubbles consisting two parallel, separated single-stranded DNA under tension, and a new form of base-paired double-stranded DNA. The existence of the three transitions has been heavily discussed among scientists for some 17 years.

    To fully understand the nature of DNA overstretching, the team led by Assoc Prof Yan, which comprises members from NUS, the University of Minnesota and the Massachusetts Institute of Technology, explored the possible structural transitions.

    Three Distinct Transitions Revealed

    In their recent study, the researchers systematically investigated the three possible transitions induced by mechanical stretching, with methods to control DNA construct, temperature, force and salt concentration. Their data successfully identified all the three proposed structures and fully characterised their respective thermo-mechanical properties. These findings were first published on the online version of the Proceedings of the National Academy of Sciences on 19 February 2013. These findings complete the picture about the structures of DNA under tension, providing a conclusion to the 17-year-old debate.

    Biological Implications and Potential Applications

    As forces over a wide range are present in the DNA of cells, the researchers' findings provide new perspectives of possible force-dependent regulations of critical biological processes, such as DNA damage repair and gene transcriptions.

    In addition, as many recently developed DNA devices are based on thermo-mechanical properties of various DNA structural motifs, these findings may also have potential applications in designing new DNA devices for the future.

    The Next Step

    To further their research, Assoc Prof Yan and his team will study the physiological functions of the three overstretched DNA structures, and investigate the presence of any new DNA structures under other mechanical constraints.

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    Story Source:

    The above story is reprinted from materials provided by National University of Singapore.

    Note: Materials may be edited for content and length. For further information, please contact the source cited above.


    Note: If no author is given, the source is cited instead.

    Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

    Source: http://feeds.sciencedaily.com/~r/sciencedaily/strange_science/~3/UdUdRvs5FAo/130228080240.htm

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    Man and woman, preferably married, wanted for expedition to Mars

    CAPE CANAVERAL, Florida, - A nonprofit foundation wants to recruit a man and a woman - possibly a married couple - for a bare-bones, 501-day journey to Mars and back that would start in less than five years, project organizers said on Wednesday.

    The mission, expected to cost upwards of $1 billion, would be privately financed by donations and sponsorships.

    Project founder Dennis Tito, a multimillionaire who in 2001 paid $20 million for a trip to the International Space Station, said he will pay start-up costs for two years to begin development of life-support systems and other critical technologies.

    Currently, there are no U.S. human spaceships in operation, but several are under development and expected to be flying by 2017.

    That leaves little time to take advantage of a rare planetary alignment that would allow a craft to loop around Mars, coming as close as about 150 miles to the planet's surface, before returning to Earth.

    The launch window for the mission opens on January 5, 2018. The next opportunity is not until 2031.

    "If we don't make 2018, we're going to have some competition in 2031," Tito told Reuters.

    "By that time, there will be many others that will be reaching for this low-hanging fruit, and it really is low-hanging fruit," said Tito, who set up the nonprofit Inspiration Mars Foundation to organize the mission.

    Project chief technical officer Taber MacCallum said U.S. industry is up for the challenge.

    "That's the kind of bold thing we used to be able to do," said MacCallum, who also oversees privately owned Paragon Space Development Corp.

    "We've shirked away from risk. I think just seriously contemplating this mission recalibrates what we believe is a risk worth taking for America," he said.

    TIGHT QUARTERS

    The spacecraft will be bare-bones, with about 600 cubic feet (17 cubic meters) of living space available for a two-person crew. Mission planners would like to fly a man and a woman, preferably a married couple who would be compatible during a long period of isolation.

    The capsule would be outfitted with a life-support system similar to the one NASA uses on the space station, which recycles air, water, urine and perspiration.

    "This is going to be a very austere mission. You don't necessarily have to follow all of NASA's guidelines for air quality and water quality. This is going to be a Lewis and Clark trip to Mars," MacCallum said, referring to the explorers who set out across the uncharted American Northwest in 1803.

    If launch occurs on January 5, 2018, the capsule would reach Mars 228 days later, loop around its far side and slingshot back toward Earth.

    The return trip takes 273 days and ends with an unprecedented 31,764-mph (51,119-kph) slam into Earth's atmosphere.

    Once the spaceship is on its way, there is no turning back.

    "If something goes wrong, they're not coming back," MacCallum said.

    The crew would spend much of their time maintaining their habitat, conducting science experiments and keeping in touch with people on Earth.

    Tito said he expects the cost to be similar to a robotic mission to Mars. NASA's ongoing Curiosity rover mission cost $2.5 billion. A follow-on mission scheduled to launch in 2020 is expected to run $1.5 billion.

    "You're really flying this mission without a propulsion system on the spacecraft. It's in the most simple form," Tito said.

    NASA is working on its own heavy-lift rocket and Orion space capsule that could carry crews of four to an asteroid and eventually to Mars.

    "We can just barely, every 15 years, fly by Mars with the systems we have right now," MacCallum said. "We're trying to be a stepping-stone."

    (Editing by Jane Sutton and Xavier Briand)

    Source: http://news.yahoo.com/man-woman-preferably-married-wanted-expedition-mars-004905145.html

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    Italy's centre-left rules out grand coalition: paper

    MILAN (Reuters) - Italy's centre-left will not form any grand coalition with Silvio Berlusconi's centre-right group after inconclusive parliamentary elections earlier this week, left-wing leader Pier Luigi Bersani said in an interview on Friday.

    "I want to spell it out clearly: the idea of a grand coalition does not exist and will never exist," Bersani told La Repubblica newspaper.

    A huge protest vote in the Feb 24-25 election produced a parliament in which no single group has a workable majority and in which the anti-establishment 5-Star Movement of Beppe Grillo has a whip hand.

    The centre-left coalition has a majority in the lower house but not the Senate.

    Bersani said he would present a 7-8 point agenda when summoned for consultations by Italy's President Giorgio Napolitano, who will have the task of forming the new government.

    He said he would put himself forward as candidate for prime minister.

    When asked if it would be a minority government, Bersani said "call it what you will. For me it is a government of change."

    Bersani did not directly reply to questions about the role of the 5-Star movement, which has said in the past it won't form alliances with Italy's traditional parties.

    (Reporting By Stephen Jewkes)

    Source: http://news.yahoo.com/italys-centre-left-rules-grand-coalition-paper-065906497.html

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